the science of a hangover

If you have been having a good time in The Six, Muskoka, or Las Vegas and are feeling run-down and "fuzzy," Hangover's Redemption may be the treatment you need to get you back on track.

Alcohol  induces a state of dehydration in the body by inhibiting the anti-diuretic hormone (ADH) secreted by the pituitary gland. This causes frequent urination, and dehydration. Aggressive re-hydration is important in acute alcohol withdrawal recovery. Replacement of other key nutrients like folate (B9), riboflavin (B2), thiamine (B1), cobalamin (B12), zinc and magnesium have also been shown to reduce the symptoms of acute alcohol withdrawal (2),(3). Studies have also shown magnesium can relieve various kinds of headaches, which is often depleted by alcohol use.

In addition to dehydration, drinking increases your levels of oxidative stress. When you drink alcohol 2 to 8 percent of this is lost through urine, sweat, or the breath. The remaining 92 to 98 % is metabolized by your body. Ethyl alcohol which is broken down in the human body is first converted to acetaldehyde, and then this acetaldehyde is converted into acetic acid radicals--also known as acetyl radicals. In this  heightened oxidative stress state your cells are exposed to high levels of oxidants and free radicals, increased hydrogen peroxide production and decreased nitric oxide production (a vasodialator: maintains potency of our blood vessels  allowing adequate blood flow to tissues). In a nutshell, this puts your mitochondria—which are the 'ENERGY MANUFACTURERS' of ATP (aka ENERGY) within our cells —under duress. ATP is often coined the "molecular unit of currency" or of intracellular energy transfer. (2) 

To mitigate this, you need to increase your intake of antioxidants such as Glutathione and vitamin C.  Both powerful antioxidants.  

At Kate Nicole we carefully assess the physiologic response of your body to alcohol and the science of a hangover to customize the best IV Vitamin Infusion Formula to help you get back in the game of Life, ASAP!



1. .Karadayian A G, Cutrera RA.  Alcohol hangover: type and time-extension of motor function impairments. Behavioural brain research, 247, 165-173.

2. Knowles, J. R. (1980). "Enzyme-catalyzed phosphoryl transfer reactions". Annu. Rev. Biochem. 49: 877–919. PMID 6250450. doi:10.1146/annurev.bi.49.070180.004305.

3. Prior PL, Vaz MJ, Ramos AC, Galduróz JCF. Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome Alcohol and Alcoholism, 50(2), 152-156.

4.Heese P, Linnebank M, Semmler A, Muschler MA, Heberlein A, Frieling H, Hillemacher T. Alterations of homocysteine serum levels during alcohol withdrawal are influenced by folate and riboflavin: results from the German Investigation on Neurobiology in Alcoholism (GINA). Alcohol and alcoholism, 47(5), 497-500